RIBOFLAVIN AS A PROMISING ANTIMICROBIAL AGENT? A MULTI-PERSPECTIVE REVIEW



Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A)

Histone lysine specific demethylase 1 (LSD1) has been recognized as an important modulator in post-translational process in epigenetics.Dysregulation of LSD1 has been implicated in the development of various cancers.Herein, we report the discovery of the hit compound 8a (IC50 = 3.93 μmol/L) and further medicinal chemistry efforts, leading to the

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Evolution of the Shadow Effect with Film Thickness and Substrate Conductivity on a Hemispherical Workpiece during Magnetron Sputtering

When depositing films on a complex workpiece surface by magnetron sputtering, the shadow effect occurs and causes the columnar structure to tilt toward the substrate owing to the oblique incident angle of the Mens Tank Tops plasma flux, affecting the microstructure and properties of the films.Improving the surface diffusion could alleviate the shad

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